Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

Yao, Liudi; Conforti, Franco; Hill, Charlotte; A. Bell, Joseph; Drawater, Leena; Li, Juanjuan; Liu, Dian; Xiong, Hua; Alzetani, Aiman; Chee, Serena; G. Marshall, Ben; Fletcher, Sophie; C. Hancock, David; J. Coldwell, Mark; Yuan, Xianglin; H. Ottensmeier, Christian; Downward, Julian; Collins, Jane; M. Ewing, Rob; Richeldi, Luca; Skipp, Paul; G. Jones, Mark; E. Davies, Donna; Wang, Yihua

doi:10.1038/s41418-018-0175-7

Public

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

Published in Cell Death and Differentiation • Jul 26, 2018

Authors:

Liudi Yao

Franco Conforti

Charlotte Hill

Abstract

The contribution of epithelial-mesenchymal transition (EMT) to human lung fibrogenesis is controversial. Here we provide evidence that ZEB1-mediated EMT in human alveolar epithelial type II (ATII) cells contributes to the development of lung fibrosis by paracrine signalling to underlying fibroblasts...

Subject

Paracrine signalling

Extracellular matrix

Myofibroblast

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