Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B and CYP3A families such as rifampicin. While assessing CYP2D6 activity under basal conditions and after pretreatment with rifampicin in vivo, we surprisingly ... View More