Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy

Li, Ruibin; Xin, Ting; Li, Dandan; Wang, Chengbin; Zhu, Hang; Zhou, Hao

doi:10.1016/j.redox.2018.07.011

Public

Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy

Published in Redox Biology • Jul 20, 2018

Authors:

Ruibin Li

Ting Xin

Dandan Li

Abstract

Increased mitochondrial damage is related to the progression of a diet-induced nonalcoholic fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating nonalcoholic fatty liver disease with a focus on mitophagy and the ERK-CREB pathway. Our data indicated th...

Subject

Mitophagy

SIRT3

Sirtuin

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