Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule‐associated protein TAU mutations which displays several phenotypes linked to neurodegeneration

Antonio García‐León, Juan; Cabrera‐Socorro, Alfredo; Eggermont, Kristel; Swijsen, Ann; Terryn, Joke; Fazal, Raheem; Nami, FatemehArefeh; Ordovás, Laura; Quiles, Ana; Lluis, Frederic; Serneels, Lutgarde; Wierda, Keimpe; Sierksma, Annerieke; Kreir, Mohamed; Pestana, Francisco; Van Damme, Philip; De Strooper, Bart; Thorrez, Lieven; Ebneth, Andreas; M. Verfaillie, Catherine

doi:10.1016/j.jalz.2018.05.007

Public

Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule‐associated protein TAU mutations which displays several phenotypes linked to neurodegeneration

Shared by NobleBlocks on Jul 20, 2018 • 12:00 AM UTC

Authors:

Juan Antonio García‐León

Alfredo Cabrera‐Socorro

Kristel Eggermont

Abstract

Abstract Introduction Tauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but none of them faithfully recapitulates human pathology and are not suita...

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