A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer

Saito, Tomoko; Niida, Atsushi; Uchi, Ryutaro; Hirata, Hidenari; Komatsu, Hisateru; Sakimura, Shotaro; Hayashi, Shuto; Nambara, Sho; Kuroda, Yosuke; Ito, Shuhei; Eguchi, Hidetoshi; Masuda, Takaaki; Sugimachi, K; Tobo, Taro; Nishida, Haruto; Daa, Tsutomu; Chiba, Kenichi; Shiraishi, Yuichi; Yoshizato, Tetsuichi; Kodama, Masaaki; Okimoto, Tadayoshi; Mizukami, Kazuhiro; Ogawa, Ryo; Okamoto, Kazuhisa; Shuto, Mitsutaka; Fukuda, Kensuke; Matsui, Yusuke; Shimamura, Teppei; Hasegawa, Takanori; Doki, Yuichiro�; Nagayama, Satoshi; Yamada, Kazutaka; Kato, Mamoru; Shibata, Tatsuhiro; Mori, Masaki; Aburatani, Hiroyuki; Murakami, Kazunari; Suzuki, Yutaka; Ogawa, Seishi; Miyano, Satoru; Mimori, Koshi

doi:10.1038/s41467-018-05226-0

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A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer

Published in Nature Communications • Jul 17, 2018

Authors:

Tomoko Saito

Atsushi Niida

Ryutaro Uchi

Abstract

Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, intratumor heterogeneity in colorectal precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early colorectal tumors, which contained adenoma and c...

Subject

KRAS

Colorectal cancer

Tumor heterogeneity

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