RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure

Jain, Mamta; Mann, Tomer; Stulić, Maja; Rao, Shailaja; Kirsch, Andrijana; Pullirsch, Dieter; Strobl, Xué; Rath, Claus; F. Reissig, Lukas; Moreth, Kristin; Klein‐Rodewald, Tanja; Bekeredjian, Raffi; Gailus‐Durner, Valérie; Fuchs, Helmut; Hrabě de Angelis, Martin; Pablik, Eleonore; Cimatti, Laura; I. K. Martin, David; Zinnanti, Jelena; F. Graier, Wolfgang; Sibilia, Maria; Frank, Saša; Y. Levanon, Erez; F. Jantsch, Michael

doi:10.15252/embj.201694813

Public

RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure

Published in The EMBO Journal • Aug 7, 2018

Authors:

Mamta Jain

Tomer Mann

Maja Stulić

Abstract

Epitranscriptomic events such as adenosine-to-inosine (A-to-I) RNA editing by ADAR can recode mRNAs to translate novel proteins. Editing of the mRNA that encodes actin crosslinking protein Filamin A (FLNA) mediates a Q-to-R transition in the interactive C-terminal region. While FLNA editing is conse...

Subject

Biology

Library science

Computer science

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