Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment

Zhang, Kaiyue; Zhao, Xiangnan; Chen, Xiaoniao; Wei, Yongzhen; Du, Wei; Wang, Yuebing; Liu, Linan; Zhao, Weian; Han, Zhibo; Kong, Deling; Zhao, Qiang; Guo, Zhikun; Han, Zhongchao; Liu, Na; Ma, Fengxia; Li, Zongjin

doi:10.1021/acsami.8b08449

Public

Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment

Published in ACS Applied Materials & Interfaces • Aug 17, 2018

Authors:

Kaiyue Zhang

Xiangnan Zhao

Xiaoniao Chen

Abstract

Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for cell-free treatment of various diseases. However, maintaining the retention and stability of exosomes over time in vivo after transplantation is a major challenge in the clinical application of MSC-derived exosom...

Subject

Microvesicles

Mesenchymal stem cell

Angiogenesis

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