The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

L. Scott, Charlotte; T’Jonck, Wouter; Martens, Liesbet; Todorov, Helena; Sichien, Dorine; Soen, Bieke; Bonnardel, Johnny; De Prijck, Sofie; Vandamme, Niels; Cannoodt, Robrecht; Saelens, Wouter; Vanneste, Bavo; Toussaint, Wendy; De Bleser, Pieter; Takahashi, Nozomi; Vandenabeele, Peter; Henri, Sandrine; Pridans, Clare; Hume, David; N. Lambrecht, Bart; De Baetselier, Patrick; Milling, Simon; A. Van Ginderachter, Jo; MALISSEN, Bernard; Berx, Geert; Beschin, Alain; Saeys, Yvan; Guilliams, Martin

doi:10.1016/j.immuni.2018.07.004

Public

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

Published in Immunity • Jul 31, 2018

Authors:

Charlotte L. Scott

Wouter T’Jonck

Liesbet Martens

Abstract

Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages remain largely unknown. The transcription factor ZEB2 is best described for its role in epithelial to mesenchymal transition; however, its role wi...

Subject

Biology

Transcription factor

Cell biology

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