Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

Feng, Bing; Zhou, Fangyuan; Hou, Bo; Wang, Dangge; Wang, Tingting; Fu, Yuanlei; Ma, Yuting; Yu, Haijun; Li, Yaping

doi:10.1002/adma.201803001

Public

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

Published in Advanced Materials • Jul 31, 2018

Authors:

Bing Feng

Fangyuan Zhou

Bo Hou

Abstract

Checkpoint blockade immunotherapy is promising for clinical treatment of various malignant tumors. However, checkpoint blockade immunotherapy suffers from a low response rate due to insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (ITM). In this study, a tumor-micro...

Subject

Tumor microenvironment

Cancer research

Immunotherapy

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