Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

A. Lees, John; Ferwerda, Bart; H. C. Kremer, Philip; E. Wheeler, Nicole; Valls Serón, Mercedes; J. Croucher, Nicholas; A. Gladstone, Rebecca; J. Bootsma, Hester; Y. Rots, Nynke; J. Wijmega-Monsuur, Alienke; A. M. Sanders, Elisabeth; Trzciński, Krzysztof; L. Wyllie, Anne; H. Zwinderman, Aeilko; H. van den Berg, Leonard; van Rheenen, Wouter; H. Veldink, Jan; Barrella Harboe, Zitta; Fogt Lundbo, Lene; de Groot, C.P.G.M.; M. van Schoor, Natasja; van der Velde, Nathalie; Ängquist, Lars; I. A. Sørensen, Thorkild; A. Nøhr, Ellen; J. Mentzer, Alexander; C. Mills, Tara; C. Knight, Julian; du Plessis, Mignon; Nzenze, Susan; N. Weiser, Jeffrey; Parkhill, Julian; A. Madhi, Shabir; Benfield, Thomas; von Gottberg, Anne; van der Ende, Arie; C. Brouwer, Matthijs; C. Barrett, Jeffrey; D. Bentley, Stephen; van de Beek, Diederik

doi:10.1038/s41467-019-09976-3

Public

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Published in Nature Communications • May 15, 2019

Authors:

John A. Lees

Bart Ferwerda

Philip H. C. Kremer

Abstract

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a gen...

Subject

Streptococcus pneumoniae

Biology

Meningitis

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