Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults

Menzies, Dick; Adjobimey, Mênonli; Ruslami, Rovina; Trajman, Anete; Bah Sow, Oumou; Jin Kim, Hee; Obeng Baah, Joseph; B. Marks, Guy; Long, Richard; Hoeppner, Vernon; Elwood, Kevin; Al‐Jahdali, Hamdan; Gninafon, M.; Apriani, Lika; Cundarani Koesoemadinata, Raspati; Lineu Kritski, Afrânio; C. Rolla, Valéria; Bah, Boubacar; Camara, Alioune; Boakye, Isaac; J. Cook, Victoria; Goldberg, Hazel; Valiquette, Chantal; Hornby, Karen; Dion, Marie-Josée; Li, Peizhi; C. Hill, Philip; Schwartzman, Kevin; Benedetti, Andrea

doi:10.1056/nejmoa1714283

Public

Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults

Published in New England Journal of Medicine • Aug 1, 2018

Authors:

Dick Menzies

Mênonli Adjobimey

Rovina Ruslami

Abstract

BACKGROUND: A 9-month regimen of isoniazid can prevent active tuberculosis in persons with latent tuberculosis infection. However, the regimen has been associated with poor adherence rates and with toxic effects. METHODS: In an open-label trial conducted in nine countries, we randomly assigned adult...

Subject

Isoniazid

Tuberculosis

Medicine

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