Inhibition of JNK and p38 MAPK‐mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin‐induced diabetic cardiomyopathy

Zuo, Guang‐Feng; Ren, Xiao‐Min; Qian, Xuesong; Ye, Peng; Luo, Jie; Gao, Xiaofei; Zhang, Junjie; Chen, Shao‐Liang

doi:10.1002/jcp.27070

Public

Inhibition of JNK and p38 MAPK‐mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin‐induced diabetic cardiomyopathy

Published in Journal of Cellular Physiology • Aug 1, 2018

Authors:

Guang‐Feng Zuo

Xiao‐Min Ren

Xuesong Qian

Abstract

Inflammation plays a critical role in the development of diabetic cardiomyopathy (DCM), which has been identified as a major predisposing factor for heart failure in diabetic patients. Previous studies indicated that ivabradine (a specific agent for heart rate [HR] reduction) has anti-inflammatory p...

Subject

Ivabradine

Diabetic cardiomyopathy

p38 mitogen-activated protein kinases

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