Endothelial Cells Harbouring the JAK2V617F Mutation Display Pro-Adherent and Pro-Thrombotic Features

Guadall, Anna; Lesteven, Élodie; Letort, Gil; Awan Toor, Sarah; Delord, Marc; Pognant, Doriane; Brusson, Mégane; Verger, Emmanuelle; Maslah, Nabih; Giraudier, Stéphane; Larghero, Jérôme; Vanneaux, Valérie; Chomienne, Christine; El Nemer, Wassim; Cassinat, Bruno; Kiladjian, Jean‐Jacques

doi:10.1055/s-0038-1667015

Public

Endothelial Cells Harbouring the JAK2V617F Mutation Display Pro-Adherent and Pro-Thrombotic Features

Published in Thrombosis and Haemostasis • Aug 13, 2018

Authors:

Anna Guadall

Élodie Lesteven

Gil Letort

Abstract

Abstract Thromboembolic events are the main cause of mortality in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) but their underlying mechanisms are largely unrecognized. The Janus kinase 2 (JAK2)V617F mutation is the most frequent genetic alteration leading to MPN. Usually found in haematopo...

Subject

Phenotype

Mutation

Von Willebrand factor

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