Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

D. Young, Matthew; J. Mitchell, Thomas; A. Vieira Braga, Felipe; Tran, Maxine; J. Stewart, Benjamin; R. Ferdinand, John; Collord, Grace; A. Botting, Rachel; Popescu, Dorin-Mirel; W. Loudon, Kevin; Vento‐Tormo, Roser; Stephenson, Emily; Cagan, Alex; J. Farndon, Sarah; Del Castillo Velasco‐Herrera, Martin; Guzzo, Charlotte; Richoz, Nathan; Mamanova, Lira; Aho, Tevita; N. Armitage, James; C. P. Riddick, Antony; Mushtaq, Imran; Farrell, Stephen; Rampling, Dyanne; C. Nicholson, James; Filby, Andrew; Burge, Johanna; Lisgo, Steven; H. Maxwell, Patrick; Lindsay, Susan; Y. Warren, Anne; D. Stewart, Grant; J. Sebire, Neil; Coleman, Nicholas; Haniffa, Muzlifah; A. Teichmann, Sarah; R. Clatworthy, Menna; Behjati, Sam

doi:10.1126/science.aat1699

Public

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

Published in Science • Aug 10, 2018

Authors:

Matthew D. Young

Thomas J. Mitchell

Felipe A. Vieira Braga

Abstract

Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We mat...

Subject

Transcriptome

Identity (music)

Cell

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