The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

Berla Thangam, E.; Angel Jemima, E.; Singh, Himadri; Saqib Baig, Mirza; Khan, Mahejibin; B. Mathias, Clinton; K. Church, Martin; Saluja, Rohit

doi:10.3389/fimmu.2018.01873

Public

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

Published in Frontiers in Immunology • Aug 13, 2018

Authors:

E. Berla Thangam

E. Angel Jemima

Himadri Singh

Abstract

Histamine and its receptors (H1R-H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body. H1R are expressed in many cells, including mast ce...

Subject

Histamine

Mast cell

Immunology

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