A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

Phillips, Tycel; M. Barr, Paul; I. Park, Steven; S. Kolibaba, Kathryn; F. Caimi, Paolo; Chhabra, Saurabh; Kingsley, Edwin; E. Boyd, Thomas; Chen, Robert; Carret, Anne‐Sophie; M. Gartner, Elaina; Li, Hong; Chen Yu, Cindy; C. Smith, David

doi:10.1007/s10637-018-0655-0

Public

A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

Published in Investigational New Drugs • Aug 22, 2018

Authors:

Tycel Phillips

Paul M. Barr

Steven I. Park

Abstract

Purpose This first-in-human study evaluated SGN-CD70A, an antibody-drug conjugate (ADC) directed against the integral plasma membrane protein CD70 and linked to a pyrrolobenzodiazepine (PBD) dimer, in patients with relapsed or refractory (R/R) CD70-positive non-Hodgkin lymphoma (NHL) including diffu...

Subject

Medicine

Lymphoma

Mantle cell lymphoma

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!