Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases

Hahn, Jonas; Schauer, Christine; Czegley, Christine; Kling, Lasse; Petrů, Lenka; Schmid, Benjamin; Weidner, Daniela; Reinwald, Christiane; Biermann, Mona; Blunder, Stefan; Ernst, J.; Lesner, Adam; Bäuerle, Tobias; Palmisano, Ralf; Christiansen, Silke; Herrmann, Martin; Bözec, Aline; Gruber, Robert; Schett, Georg; Hoffmann, Markus

doi:10.1096/fj.201800752r

Public

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases

Published in The FASEB Journal • Aug 21, 2018

Authors:

Jonas Hahn

Christine Schauer

Christine Czegley

Abstract

ABSTRACT Papillon‐Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)‐associated aggregation and cytokine/chemokine‐release/degradation by normal ...

Subject

Neutrophil extracellular traps

Chemokine

Inflammation

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