Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials

F. Chemaly, Roy; Chou, Sunwen; Einsele, Hermann; Griffiths, Paul; K. Avery, Robin; R. Razonable, Raymund; M. Mullane, Kathleen; N. Kotton, Camille; Lundgren, Jens; Komatsu, Takashi; Lischka, Peter; Josephson, Filip; Douglas, Cameron; Umeh, Obi; Miller, Veronica; Ljungman, Per; Definitions Working Group of the Cytomegalovirus Drug Development Forum, Resistant

doi:10.1093/cid/ciy696

Public

Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials

Published in Clinical Infectious Diseases • Aug 17, 2018

Authors:

Roy F. Chemaly

Sunwen Chou

Hermann Einsele

Abstract

Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major complication in solid organ and hematopoietic cell transplant recipients. CMV infection may fail to respond to commercially available antiviral therapies, with or without demonstrating genotypic mutation(s) kn...

Subject

Medicine

Refractory (planetary science)

Cytomegalovirus infection

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