Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

A. Tawbi, Hussein; Forsyth, Peter; P. Algazi, Alain; Hamid, Omid; Stephen Hodi, F.; J. Moschos, Stergios; I. Khushalani, Nikhil; D. Lewis, Karl; D. Lao, Christopher; A. Postow, Michael; B. Atkins, Michael; S. Ernstoff, Marc; A. Reardon, David; Puzanov, Igor; R. Kudchadkar, Ragini; Thomas, Reena; A. Tarhini, Ahmad; C. Pavlick, Anna; Jiang, Joel; Avila, Alexandre; Demelo, Sheena; Margolin, Kim

doi:10.1056/nejmoa1805453

Public

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Published in New England Journal of Medicine • Aug 22, 2018

Authors:

Hussein A. Tawbi

Peter Forsyth

Alain P. Algazi

Abstract

BACKGROUND: Brain metastases are a common cause of disabling neurologic complications and death in patients with metastatic melanoma. Previous studies of nivolumab combined with ipilimumab in metastatic melanoma have excluded patients with untreated brain metastases. We evaluated the efficacy and sa...

Subject

Ipilimumab

Nivolumab

Medicine

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