Mesenchymal Stem Cells Modified with Heme Oxygenase-1 Have Enhanced Paracrine Function and Attenuate Lipopolysaccharide-Induced Inflammatory and Oxidative Damage in Pulmonary Microvascular Endothelial Cells

Chen, Xuxin; Zhang, Yinliang; Wang, Wenjing; Liu, Zhenqian; Meng, Jiguang; Han, Zhihai

doi:10.1159/000492847

Public

Mesenchymal Stem Cells Modified with Heme Oxygenase-1 Have Enhanced Paracrine Function and Attenuate Lipopolysaccharide-Induced Inflammatory and Oxidative Damage in Pulmonary Microvascular Endothelial Cells

Published in Cellular Physiology and Biochemistry • Jan 1, 2018

Authors:

Xuxin Chen

Yinliang Zhang

Wenjing Wang

Abstract

BACKGROUND/AIMS: Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has therapeutic effects on endothelial damage during acute lung injury (ALI). Heme oxygenase-1 (HO-1) can restore homeostasis and implement cytoprotective defense functions in many pathologic states. Therefore, we ex...

Subject

Heme oxygenase

Mesenchymal stem cell

Superoxide dismutase

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