Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death

Ueki, Shigeharu; Tokunaga, Takahiro; C. N. Melo, Rossana; Saito, Hidekazu; Honda, Kohei; Fukuchi, Mineyo; Konno, Yasunori; Takeda, Masahide; Yamamoto, Yohei; Hirokawa, Makoto; Fujieda, Shigeharu; A. Spencer, Lisa; F. Weller, Peter

doi:10.1182/blood-2018-04-842260

Public

Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death

Published in Blood • Aug 28, 2018

Authors:

Shigeharu Ueki

Takahiro Tokunaga

Rossana C. N. Melo

Abstract

Protein crystallization in human tissue rarely occurs. Charcot-Leyden crystals (CLCs) were described in various eosinophilic diseases >150 years ago, but our understanding of CLC formation still remains limited. In this study, we demonstrate that CLCs observed in varied inflamed human tissues are cl...

Subject

Extracellular

Neutrophil extracellular traps

Cytoplasm

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