Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression.

CD, Staton; JDW, Yaeger; D, Khalid; F, Haroun; BS, Fernandez; JS, Fernandez; BK, Summers; TR, Summers; M, Sathyanesan; SS, Newton; CH, Summers

doi:10.1016/j.neuropharm.2018.09.016

Public

Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression.

Shared by NobleBlocks on Sep 18, 2018 • 12:00 AM UTC

Authors:

Staton CD

Yaeger JDW

Khalid D

Abstract

Knockdown of orexin/hypocretin 2 receptor (Orx2) in the basolateral amygdala (BLA) affects anxious and depressive behavior. We use a new behavioral paradigm, the Stress Alternatives Model (SAM), designed to improve translational impact. The SAM induces social stress in adult male mice by aggression ...

Subject

Susceptibility

Freezing

Depression

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