Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development

Internal modification of RNAs with N 6 -methyladenosine (m 6 A) is a highly conserved means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark on thousands of transcripts in a single-stranded context, the substrate requirements and physiological roles of the second m 6 A... View More