Pharmacokinetics of intramuscular alfaxalone and its echocardiographic, cardiopulmonary and sedative effects in healthy dogs

Cruz Benedetti, Inga‐Catalina; Bublot, Isabelle; Ribas, Thibault; Fourel, Isabelle; Vogl, Claus; Dubois, Claire; Milani, Mathilde; Kazue Ida, Keila; Portier, Karine

doi:10.1371/journal.pone.0204553

Public

Pharmacokinetics of intramuscular alfaxalone and its echocardiographic, cardiopulmonary and sedative effects in healthy dogs

Published in PLoS ONE • Sep 24, 2018

Authors:

Inga‐Catalina Cruz Benedetti

Isabelle Bublot

Thibault Ribas

Abstract

The pharmacokinetics and the effects of a single intramuscular (IM) dose of alfaxalone on sedation and cardiopulmonary and echocardiographic variables was studied in dogs. Twelve healthy adult Beagles (3 females, 9 males) were used in this prospective controlled cross-over trial. Echocardiography wa...

Subject

Sedation

Medicine

Anesthesia

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