Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy

Fang, Jian; Zhang, Shangwu; Xue, Xiaofeng; Zhu, Xinguo; Song, Shiduo; Wang, Bin; Jiang, Lin‐Hua; Qin, Mingde; Liang, Hansi; Gao, Ling

doi:10.2147/ijn.s170862

Public

Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy

Published in International Journal of Nanomedicine • Sep 1, 2018

Authors:

Jian Fang

Shangwu Zhang

Xiaofeng Xue

Abstract

BACKGROUND: Effective gastric carcinoma (GC) chemotherapy is subject to many in vitro and in vivo barriers, such as tumor microenvironment and multidrug resistance. MATERIALS AND METHODS: Herein, we developed a hyaluronic acid (HA)-modified silica nanoparticle (HA-SiLN/QD) co-delivering quercetin an...

Subject

Doxorubicin

In vivo

Multiple drug resistance

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