PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

Gentric, Géraldine; Kieffer, Yann; Mieulet, Virginie; Goundiam, Oumou; Bonneau, Claire; Némati, Fariba; Hurbain, Ilse; Raposo, Graça; Popova, Tatiana; Stern, Marc‐Henri; Lallemand-Breitenbach, Valérie; Müller, Sebastian; Cañeque, Tatiana; Rodriguez, Raphaël; Vincent‐Salomon, Anne; de Thé, Hugues; Rossignol, Rodrigue; Mechta‐Grigoriou, Fatima

doi:10.1016/j.cmet.2018.09.002

Public

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

Published in Cell Metabolism • Sep 20, 2018

Authors:

Géraldine Gentric

Yann Kieffer

Virginie Mieulet

Abstract

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic, metabolomic, and bioergenetic analyses, we identify two molecular subgroups, low- and high-OXPHOS. While low-OXPHOS exhibit a glyco...

Subject

Oxidative phosphorylation

Oxidative stress

Mitochondrion

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