Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3

Kawane, Tetsuya; Qin, Xin; Jiang, Qing; Miyazaki, Toshihiro; Komori, Hisato; A. Yoshida, Carolina; Keiko dos Santos Matsuura-Kawata, Viviane; Sakane, Chiharu; Matsuo, Yuki; Nagai, Kazuhiro; Maeno, Takafumi; Date, Yuki; Nishimura, Riko; Komori, Toshihisa

doi:10.1038/s41598-018-31853-0

Public

Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3

Published in Scientific Reports • Sep 4, 2018

Authors:

Tetsuya Kawane

Xin Qin

Qing Jiang

Abstract

Abstract Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the molecular mechanisms responsible for the proliferation of osteoblast progenitors remain unclear. The early onset of Runx2 expression caused limb defects through the Fgfr1 –3 regulation by Runx2. T...

Subject

RUNX2

Osteoblast

Progenitor cell

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