Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation

Cai, Helen; S. Catts, Vibeke; J. Webster, Maree; Galletly, Cherrie; Liu, Dennis; O׳Donnell, Maryanne; W. Weickert, Thomas; Shannon Weickert, Cynthia

doi:10.1038/s41380-018-0235-x

Public

Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation

Published in Molecular Psychiatry • Sep 11, 2018

Authors:

Helen Cai

Vibeke S. Catts

Maree J. Webster

Abstract

Elevated pro-inflammatory cytokines exist in both blood and brain of people with schizophrenia but how this affects molecular indices of the blood-brain barrier (BBB) is unclear. Eight mRNAs relating to BBB function, a microglia and three immune cell markers were measured by qPCR in the prefrontal c...

Subject

Schizophrenia (object-oriented programming)

Inflammation

Frontal cortex

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