Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

W. Renz, Bernhard; Tanaka, Takayuki; Sunagawa, Masaki; Takahashi, Ryota; Jiang, Zhengyu; Macchini, Marina; Dantes, Zahra; Valenti, Giovanni; A. White, Ruth; Middelhoff, Moritz; Ilmer, Matthias; E. Oberstein, Paul; K. Angele, Martin; Deng, Huan; Hayakawa, Yoku; Benedikt Westphalen, C.; Werner, Jens; Remotti, Helen; Reichert, Maximilian; Tailor, Yagnesh; Nagar, Karan; A. Friedman, Richard; C. Iuga, Alina; P. Olive, Kenneth; C. Wang, Timothy

doi:10.1158/2159-8290.cd-18-0046

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Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

Published in Cancer Discovery • Sep 5, 2018

Authors:

Bernhard W. Renz

Takayuki Tanaka

Masaki Sunagawa

Abstract

Abstract In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been defined. Here, we found that subdiaphragma...

Subject

Muscarinic acetylcholine receptor

Carcinogenesis

Cholinergic

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