Ceftazidime‐Avibactam Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Across Adult Indications and Patient Subgroups

Li, Jianguo; Lovern, Mark; Green, Michelle; Chiu, Joannellyn; Zhou, Diansong; Comisar, Craig; Xiong, Yuan; Hing, Jeremy; Macpherson, M.; G. Wright, James; Riccobene, Todd; J. Carrothers, Timothy; Das, Shampa

doi:10.1111/cts.12585

Public

Ceftazidime‐Avibactam Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Across Adult Indications and Patient Subgroups

Published in Clinical and Translational Science • Sep 17, 2018

Authors:

Jianguo Li

Mark Lovern

Michelle Green

Abstract

Ceftazidime-avibactam is a novel β-lactam/β-lactamase inhibitor combination for the treatment of serious infections caused by resistant gram-negative pathogens. Population pharmacokinetic (PopPK) models were built to incorporate pharmacokinetic (PK) data from five phase III trials in patients with c...

Subject

Ceftazidime/avibactam

Pharmacodynamics

Medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!