Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease

M. Byrne, Lauren; B. Rodrigues, Filipe; B. Johnson, Eileanoir; A. Wijeratne, P.; De Vita, Enrico; C. Alexander, Daniel; Palermo, Giuseppe; Czech, Christian; Schobel, Scott; I. Scahill, Rachael; Heslegrave, Amanda; Zetterberg, Henrik; J. Wild, Edward

doi:10.1126/scitranslmed.aat7108

Public

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease

Published in Science Translational Medicine • Sep 12, 2018

Authors:

Lauren M. Byrne

Filipe B. Rodrigues

Eileanoir B. Johnson

Abstract

gene, for which there is currently no cure. The identification of sensitive indicators of disease progression and therapeutic outcome could help the development of effective strategies for treating HD. We assessed mutant huntingtin (mHTT) and neurofilament light (NfL) protein concentrations in cereb...

Subject

Huntingtin

Mutant

Huntington's disease

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!