Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With <i>E coli</i> or <i>Klebsiella pneumoniae</i> Bloodstream Infection and Ceftriaxone Resistance

N. A. Harris, Patrick; Anantharajah Tambyah, Paul; Chien Lye, David; Mo, Yin; H. Lee, Tau; Yılmaz, Mesut; H. Alenazi, Thamer; M. Arabi, Yaseen; Falcone, Marco; Bassetti, Matteo; Righi, Elda; A. Rogers, Benjamin; S. Kanj, Souha; Bhally, Hasan; R. Iredell, Jonathan; Mendelson, Marc; Boyles, Tom; Looke, David; Miyakis, Spiros; Walls, Genevieve; Al Khamis, Mohammed; Zikri, Ahmed; Crowe, Amy; R. Ingram, Paul; Daneman, Nick; Griffin, Paul; Athan, Eugene; Lorenc, Penelope; Baker, Peter; W. Roberts, Leah; A. Beatson, Scott; Y. Peleg, Anton; Harris‐Brown, Tiffany; L. Paterson, David

doi:10.1001/jama.2018.12163

Public

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance

Published in JAMA • Sep 11, 2018

Authors:

Patrick N. A. Harris

Paul Anantharajah Tambyah

David Chien Lye

Abstract

Importance: Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella pneumoniae. Significant infections caused by these strains are usually treated with carbapenems, potentially selecting for carbapenem resistance. Pipe...

Subject

Medicine

Meropenem

Piperacillin/tazobactam

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