Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Y. Fouda, Abdelrahman; Xu, Zhimin; Shosha, Esraa; Lemtalsi, Tahira; Chen, Ji‐Jun; A. Toque, Haroldo; Tritz, Rebekah; Cui, Xuezhi; K. Stansfield, Brian; Huo, Yuqing; C. Rodrı́guez, Paulo; B. Smith, Sylvia; W. Caldwell, Robert; William Caldwell, R.; Priya Narayanan, S.; B. Caldwell, Ruth; B. Caldwell, Ruth

doi:10.1038/s41419-018-1051-6

Public

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Published in Cell Death and Disease • Sep 25, 2018

Authors:

Abdelrahman Y. Fouda

Zhimin Xu

Esraa Shosha

Abstract

Abstract The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 (A1), in retinal ischemia-reperfusion (IR) injury. A1 competes with nitric oxide synthase (NOS) for the...

Subject

Arginase

Inflammation

Nitric oxide

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