Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer

Wang, Longqiang; Tong, Xin; Zhou, Zhengyu; Wang, Shengjie; Lei, Zhe; Zhang, Tianze; Liu, Zeyi; Zeng, Yuanyuan; Li, Chang; Zhao, Jun; Su, Zhiyue; Zhang, Cuijuan; Liu, Xia; Xu, Guangquan; Zhang, Hongtao

doi:10.1186/s12943-018-0889-7

Public

Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer

Published in Molecular Cancer • Sep 27, 2018

Authors:

Longqiang Wang

Xin Tong

Zhengyu Zhou

Abstract

BACKGROUND: TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding RNAs involved in human cancers. However, whether and how circRNAs contribute to TG...

Subject

Epithelial–mesenchymal transition

Gene knockdown

Biology

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