Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers

Komiya, Takefumi; Huang, Chao

doi:10.3389/fonc.2018.00423

Public

Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers

Published in Frontiers in Oncology • Oct 4, 2018

Authors:

Takefumi Komiya

Chao Huang

Abstract

Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a variety of cancers. However, a novel therapeutic approach is needed...

Subject

Medicine

Pembrolizumab

Indoleamine 2

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