Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

Inouye, Michael; Abraham, Gad; P. Nelson, Christopher; Wood, Angela; Sweeting, Michael; Dudbridge, Frank; Lai, Florence; Kaptoge, Stephen; Brożyńska, Marta; Wang, Tingting; Ye, Shu; R. Webb, Tom; K. Rutter, Martin; Tzoulaki, Ioanna; Patel, Riyaz; J. F. Loos, Ruth; Keavney, Bernard; Hemingway, Harry; R. Thompson, John; Watkins, Hugh; Deloukas, Panos; Di Angelantonio, Emanuele; S. Butterworth, Adam; Danesh, John; J. Samani, Nilesh

doi:10.1016/j.jacc.2018.07.079

Public

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

Published in Journal of the American College of Cardiology • Oct 1, 2018

Authors:

Michael Inouye

Gad Abraham

Christopher P. Nelson

Abstract

BACKGROUND: Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited genomic scope and limited sample siz...

Subject

Medicine

Coronary artery disease

Hazard ratio

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