Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

B. Nair, Anroop; A. Morsy, Mohamed; Jacob, Shery

doi:10.1002/ddr.21461

Public

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

Published in Drug Development Research • Oct 21, 2018

Authors:

Anroop B. Nair

Mohamed A. Morsy

Shery Jacob

Abstract

Preclinical Research & Development Appropriate translation and determination of the maximum recommended starting dose in human is a vital task in new drug development and research. Allometric scaling is the most frequently used approach for dose extrapolation based on normalization of dose-to-body s...

Subject

Drug development

Drug

Translation (biology)

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