Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

Võsa, Urmo; Claringbould, Annique; Westra, Harm-Jan; Jan Bonder, Marc; Deelen, Patrick; Zeng, Biao; Kirsten, Holger; Saha, Ashis; Kreuzhuber, Roman; Kasela, Silva; Pervjakova, Natalia; Alvaes, Isabel; Favé, Marie-Julie; Agbessi, Mawussé; Christiansen, Mark; Jansen, Rick; Seppälä, Ilkka; Lin, Tong; Teumer, Alexander; Schramm, Katharina; Hemani, Gibran; Verlouw, Joost; Yaghootkar, Hanieh; Sönmez, Reyhan; Brown, Andrew; Kukushkina, Viktorija; Kalnapenkis, Anette; Rüeger, Sina; Porcu, Eleonora; Kronberg-Guzman, Jaanika; Kettunen, Johannes; E. Powell, Joseph; Lee, Bernett; Zhang, Futao; Arindrarto, Wibowo; Beutner, Frank; Brugge, Harm; Dmitreva, Julia; Elansary, Mahmoud; P. Fairfax, Benjamin; Georges, Michel; T. Heijmans, Bastiaan; Kähönen, Mika; Kim, Yungil; C. Knight, Julian; Kovács, Péter; Krohn, Knut; Li, Shuang�; Loeffler, Markus; M. Marigorta, Urko; Mei, Hailang; Momozawa, Yukihide; Müller‐Nurasyid, Martina; Nauck, Matthias; G. Nivard, Michel; W.J.H. Penninx, Brenda; K. Pritchard, Jonathan; T. Raitakari, Olli; Rotzchke, Olaf; Eline Slagboom, P.; D.A. Stehouwer, Coen; Stümvoll, Michael; Sullivan, Patrick; A.C. ’t Hoen, Peter; Thiery, Joachim; Tönjes, Anke; van Dongen, Jenny; van Iterson, Maarten; H. Veldink, Jan; Völker, Uwe; Wijmenga, Cisca; A. Swertz, Morris; Kumar Andiappan, Anand; W. Montgomery, Grant; Ripatti, Samuli; Perola, Markus; Kutalik, Zoltán; T. Dermitzakis, Emmanouil; Bergmann, Sven; M. Frayling, Timothy; B. J. van Meurs, Joyce; Prokisch, Holger; Ahsan, Habibul; L. Pierce, Brandon; Lehtimäki, Terho; I. Boomsma, Dorret; M. Psaty, Bruce; A. Gharib, Sina; Awadalla, Philip; Milani, Lili; H. Ouwehand, Willem; Downes, Kate; Stegle, Oliver; Battle, Alexis; Yang, Jian; M. Visscher, Peter; Scholz, Markus; Gibson, Gregory; Esko, Tõnu; Franke, Lude

doi:10.1101/447367

Public

Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

Published in bioRxiv (Cold Spring Harbor Laboratory) • Oct 19, 2018

Authors:

Urmo Võsa

Annique Claringbould

Harm-Jan Westra

Abstract

Summary While many disease-associated variants have been identified through genome-wide association studies, their downstream molecular consequences remain unclear. To identify these effects, we performed cis- and trans-expression quantitative trait locus (eQTL) analysis in blood from 31,684 individ...

Subject

Expression quantitative trait loci

Genetic architecture

Genome-wide association study

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