The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein

Hiramoto, Emiri; Tsutsumi, Akihisa; Suzuki, Risa; Matsuoka, Shigeru; Arai, Satoko; Kikkawa, Masahide; Miyazaki, Toru

doi:10.1126/sciadv.aau1199

Public

The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein

Published in Science Advances • Oct 5, 2018

Authors:

Emiri Hiramoto

Akihisa Tsutsumi

Risa Suzuki

Abstract

Soluble immunoglobulin M (IgM) forms a pentamer containing a joining (J) chain polypeptide. While IgM pentamer has various immune functions, it also behaves as a carrier of circulating apoptosis inhibitor of macrophage (AIM; also called CD5L) protein that facilitates repair during different diseases...

Subject

Pentamer

Negative stain

Chemistry

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