<i>MUC5B</i> Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

Juge, Pierre‐Antoine; Lee, Joyce; Ebstein, Esther; Furukawa, Hiroshi; Dobrinskikh, Evgenia; Gazal, Steven; Kannengiesser, Caroline; Ottaviani, Sébastien; Oka, Shomi; Tohma, Shigeto; Tsuchiya, Naoyuki; Rojas‐Serrano, Jorge; I. González-Pérez, Montserrat; Mejía, Mayra; Buendía-Roldán, Ivette; Falfán‐Valencia, Ramcés; Ambrocio-Ortiz, Enrique; D. Manali, Effrosyni; A. Papiris, Spyros; Karageorgas, T.; T. Boumpas, Dimitrios; Αντωνίου, Κατερίνα; H.M. van Moorsel, Coline; van der Vis, Joanne; A de Man, Yaël; C. Grutters, Jan; Wang, Yaping; Borie, Raphaël; Wémeau-Stervinou, Lidwine; Wallaert, B.; Flipo, René‐Marc; Nunès, Hilario; Valeyre, Dominique; Saidenberg-Kermanac’h, Nathalie; Boissier, Marie‐Christophe; Marchand‐Adam, S.; Frazier, Aline; Richette, Pascal; Allanore, Yannick; Sibilia, Jean; Dromer, Claire; Richez, Christophe; Schaeverbeke, Thierry; Lioté, H.; Thabut, Gabriel; Nathan, Nadia; Amselem, Serge; Soubrier, Martin; Cottin, Vincent; Clément, Annick; D. Deane, Kevin; Walts, Avram; E. Fingerlin, Tasha; Fischer, Aryeh; H. Ryu, Jay; L. Matteson, Eric; B. Niewold, Timothy; Assayag, Deborah; Gross, Andrew; J. Wolters, Paul; I. Schwarz, Marvin; Holers, Michael; J. Solomon, Joshua; J. Doyle, Tracy; O. Rosas, Iván; Blauwendraat, Cornelis; A. Nalls, Mike; Debray, Marie‐Pierre; Boileau, Cathérine; Crestani, Bruno; A. Schwartz, David; Dieudé, Philippe

doi:10.1056/nejmoa1801562

Public

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

Published in New England Journal of Medicine • Oct 20, 2018

Authors:

Pierre‐Antoine Juge

Joyce Lee

Esther Ebstein

Abstract

BACKGROUND: Given the phenotypic similarities between rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of idiopathic pulmonary fibrosis, the gain-of-function ...

Subject

Rheumatoid arthritis

Interstitial lung disease

Medicine

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