Comparison of hepatotoxicity and mechanisms induced by triclosan (TCS) and methyl-triclosan (MTCS) in human liver hepatocellular HepG2 cells

Wang, Lu; Mao, Boyu; He, Huixin; Shang, Yu; Zhong, Yufang; Yu, Zhiqiang; Yang, Yiting; Li, Hui; An, Jing

doi:10.1039/c8tx00199e

Public

Comparison of hepatotoxicity and mechanisms induced by triclosan (TCS) and methyl-triclosan (MTCS) in human liver hepatocellular HepG2 cells

Published in Toxicology Research • Oct 11, 2018

Authors:

Lu Wang

Boyu Mao

Huixin He

Abstract

up-regulation of DNA-PKcs. In addition, TCS blocked the HepG2 cells in S and G2/M phases of cell cycle through down-regulation of cyclin A2 and CDK; while MTCS induced cell cycle arrest at the S phase through up-regulation of cyclin A2 and CDK. Furthermore, TCS activated p53 mediated apoptosis in He...

Subject

Triclosan

Hepatocellular carcinoma

Human liver

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