Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Fumet, Jean-David; Richard, Corentin; Ledys, Fanny; Klopfenstein, Quentin; Joubert, Philippe; Routy, Bertrand; Truntzer, Caroline; Gagné, Andréanne; Hamel, Marc-André; Figueiredo Guimaraes, Camila; Coudert, Bruno; Arnould, Laurent; Favier, Laure; Lagrange, Aurélie; Ladoire, Sylvain; Saintigny, Pierre; Ortiz‐Cuaran, Sandra; Pérol, M.; Foucher, Pascal; Hofman, Paul; Ilié, Marius; Chevrier, Sandy; Boidot, Romain; Dérangère, Valentin; Ghiringhelli, François

doi:10.1038/s41416-018-0220-9

Public

Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Published in British Journal of Cancer • Oct 1, 2018

Authors:

Jean-David Fumet

Corentin Richard

Fanny Ledys

Abstract

BACKGROUND: No study has evaluated the predictive and prognostic role of CD8 and PD-L1 coexpression in non-small-cell lung cancer (NSCLC). METHODS: We analyzed RNA sequencing and/or immunohistochemistry staining in NSCLC patients from The Cancer Genome Atlas (n = 1016), and 34 metastatic NSCLC sampl...

Subject

Oncology

Lung cancer

Internal medicine

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