The Role of TNF-α induced MSCs on Suppressive Inflammation by Increasing TGF-β and IL-10

Putra, Agung; Baitul Ridwan, Fatkhan; Irwaniyanti Putridewi, Allisha; Retno Kustiyah, Azizah; Wirastuti, Ken; Anna Chalimah Sadyah, Nur; Rosdiana, Ika; Munir, Delfitri

doi:10.3889/oamjms.2018.404

Public

The Role of TNF-α induced MSCs on Suppressive Inflammation by Increasing TGF-β and IL-10

Published in Open Access Macedonian Journal of Medical Sciences • Oct 4, 2018

Authors:

Agung Putra

Fatkhan Baitul Ridwan

Allisha Irwaniyanti Putridewi

Abstract

BACKGROUND: Mesenchymal stem cells (MSCs) may serve as immunoregulators by producing various anti-inflammatory molecules. Under sufficient level of TNF-α, MSCs become activated and adopt immune-suppressive phenotype (MSCs type-2) by releasing various anti-inflammatory molecule including TGF-β and IL...

Subject

Medicine

Tumor necrosis factor alpha

Mesenchymal stem cell

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