Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Ceyzériat, Kelly; Ben Haim, Lucile; Denizot, Audrey; Pommier, Dylan; Matos, Marco; Guillemaud, Océane; Palomares, Marie-Ange; Abjean, Laurene; Petit, Fanny; Gipchtein, Pauline; Gaillard, Marie‐Claude; Guillermier, Martine; Bernier, Suéva; Gaudin, Mylène; Aurégan, Gwenaëlle; Joséphine, Charlène; Déchamps, Nathalie; Veran, Julien; Langlais, Valentin; Cambon, Karine; Bemelmans, Alexis‐Pierre; Baijer, Jan; Bonvento, Gilles; Dhénain, Marc; Deleuze, Jean‐François; H. R. Oliet, Stéphane; Brouillet, Emmanuel; Hantraye, Philippe; Carrillo-de Sauvage, María-Angeles; Olaso, Robert; Panatier, Aude; Escartin, Carole

doi:10.1186/s40478-018-0606-1

Public

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Published in Acta Neuropathologica Communications • Oct 15, 2018

Authors:

Kelly Ceyzériat

Lucile Ben Haim

Audrey Denizot

Abstract

Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer's disease. However, the specific role of reactive astrocytes is still debated. This controversy may stem from the fact that most strategies used to modulate astrocyte reactivity and explore its ...

Subject

Astrocyte

Neuroscience

Alzheimer's disease

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