Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

B. Harrington, Lucas; Burstein, David; S. Chen, Janice; Paez-Espino, David; Ma, Enbo; P. Witte, Isaac; C. Cofsky, Joshua; C. Kyrpides, Nikos; F. Banfield, Jillian; A. Doudna, Jennifer

doi:10.1126/science.aav4294

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Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

Shared by NobleBlocks on Nov 16, 2018 • 12:00 AM UTC

Authors:

Lucas B. Harrington

David Burstein

Janice S. Chen

Abstract

A programmable type of CRISPR system CRISPR-Cas9 systems have been causing a revolution in biology. Harrington et al. describe the discovery and technological implementation of an additional type of CRISPR system based on an extracompact effector protein, Cas14. Metagenomics data, particularly from ...

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