N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E<sub>2</sub> to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

SS, Karuppagounder; L, Alin; Y, Chen; D, Brand; MW, Bourassa; K, Dietrich; CM, Wilkinson; CA, Nadeau; A, Kumar; S, Perry; JT, Pinto; V, Darley-Usmar; S, Sanchez; GL, Milne; D, Pratico; TR, Holman; ST, Carmichael; G, Coppola; F, Colbourne; RR, Ratan

doi:10.1002/ana.25356

Public

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Shared by NobleBlocks on Nov 29, 2018 • 12:00 AM UTC

Authors:

Karuppagounder SS

Alin L

Chen Y

Abstract

Objectives N-acetylcysteine (NAC) is a clinically approved thiol-containing redox modulatory compound currently in trials for many neurological and psychiatric disorders. Although generically labeled as an "antioxidant," poor understanding of its site(s) of action is a barrier to its use in neurolog...

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