N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Saravanan S, Karuppagounder,; Lauren, Alin,; Yingxin, Chen,; David, Brand,; Megan W, Bourassa,; Kristen, Dietrich,; Cassandra M, Wilkinson,; Colby A, Nadeau,; Amit, Kumar,; Steve, Perry,; John T, Pinto,; Victor, Darley-Usmar,; Stephanie, Sanchez,; Ginger L, Milne,; Domenico, Pratico,; Theodore R, Holman,; S Thomas, Carmichael,; Giovanni, Coppola,; Frederick, Colbourne,; Rajiv R, Ratan,

doi:10.1002/ana.25356

Public

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Published in Annals of neurology • Dec 1, 2018

Authors:

Karuppagounder, Saravanan S

Alin, Lauren

Chen, Yingxin

Abstract

OBJECTIVES: N-acetylcysteine (NAC) is a clinically approved thiol-containing redox modulatory compound currently in trials for many neurological and psychiatric disorders. Although generically labeled as an "antioxidant," poor understanding of its site(s) of action is a barrier to its use in neurolo...

Subject

Acetylcysteine

Animals

Arachidonate 5-Lipoxygenase

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