MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer.

Y, Pang; J, Liu; X, Li; G, Xiao; H, Wang; G, Yang; Y, Li; SC, Tang; S, Qin; N, Du; H, Zhang; D, Liu; X, Sun; H, Ren

doi:10.1111/jcmm.13916

Public

MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer.

Shared by NobleBlocks on Oct 16, 2018 • 12:00 AM UTC

Authors:

Pang Y

Liu J

Li X

Abstract

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with a poor prognosis. The microRNA-200 (miR-200) family has been associated with breast cancer metastasis. However, the epigenetic mechanisms underlying miR-200b repression in TNBC are not fully elucidated. In this st...

Subject

DNA methylation

MYC

Dnmt3a

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