MYC and DNMT 3A‐mediated DNA methylation represses micro RNA ‐200b in triple negative breast cancer

Pang, Yamei; Liu, Jian; Xiang, Li; Xiao, Guodong; Wang, Huangzhen; Yang, Ganghua; Li, Yanbo; Tang, Shou‐Ching; Qin, Sida; Du, Ning; Zhang, Henggang; Liu, Dapeng; Sun, Xin; Ren, Hong

doi:10.1111/jcmm.13916

Public

MYC and DNMT 3A‐mediated DNA methylation represses micro RNA ‐200b in triple negative breast cancer

Published in Journal of Cellular and Molecular Medicine • Oct 16, 2018

Authors:

Yamei Pang

Jian Liu

Li Xiang

Abstract

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with a poor prognosis. The microRNA-200 (miR-200) family has been associated with breast cancer metastasis. However, the epigenetic mechanisms underlying miR-200b repression in TNBC are not fully elucidated. In this st...

Subject

Triple-negative breast cancer

Cancer research

DNA methylation

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