The chromatin accessibility landscape of primary human cancers

Ryan Corces, M.; M. Granja, Jeffrey; Shams, Shadi; H. Louie, Bryan; A. Seoane, José; Zhou, Wanding; C. Silva, Tiago; S. Groeneveld, Clarice; K. Wong, Christopher; Woo Cho, Seung; T. Satpathy, Ansuman; R. Mumbach, Maxwell; A. Hoadley, Katherine; Gordon Robertson, A.; C. Sheffield, Nathan; Felau, Ina; A. A. Castro, Mauro; P. Berman, Benjamin; M. Staudt, Louis; C. Zenklusen, Jean; W. Laird, Peter; Curtis, Christina; Cancer Genome Atlas Analysis Network, The; J. Greenleaf, William; Y. Chang, Howard; Akbani, Rehan; C. Benz, Christopher; A. Boyle, Evan; M. Broom, Bradley; D. Cherniack, Andrew; Craft, Brian; A. Demchok, John; S. Doane, Ashley; Elemento, Olivier; L. Ferguson, Martin; J. Goldman, Mary; Neil Hayes, D.; He, Jing; Hinoue, Toshinori; Imieliński, Marcin; J.M. Jones, Steven; Kemal, Anab; Knijnenburg, Theo; Korkut, Anil; Lin, De‐Chen; Liu, Yuexin; K. A. Mensah, Michael; B. Mills, Gordon; Reuter, Vincent; Schultz, André; Shen, Hui; P. Smith, Jason; Tarnuzzer, Roy; Trefflich, Sheyla; Wang, Zhining; N. Weinstein, John; Westlake, Lindsay; Xu, Jin; Yang, Liming; Yau, Christina; Zhao, Yang; Zhu, Jingchun

doi:10.1126/science.aav1898

Public

The chromatin accessibility landscape of primary human cancers

Published in Science • Oct 26, 2018

Authors:

M. Ryan Corces

Jeffrey M. Granja

Shadi Shams

Abstract

We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from The Cancer Genome Atlas (TCGA). We identify 562,709 transposase-accessible DNA elements that substantially extend the compendium of known cis-regulatory elements. Integration of ATAC-seq (t...

Subject

Chromatin

Primary (astronomy)

Computational biology

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