Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling

Wen, Siyang; Hou, Yixuan; Fu, Lixin; Xi, Lei; Yang, Dan; Zhao, Maojia; Qin, Yilu; Sun, Kexin; Teng, Yong; Liu, Manran

doi:10.1016/j.canlet.2018.10.015

Public

Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling

Published in Cancer Letters • Oct 26, 2018

Authors:

Siyang Wen

Yixuan Hou

Lixin Fu

Abstract

Metastasis is the leading cause of breast cancer-related deaths. Cancer-associated fibroblasts (CAFs), the predominant stromal cell type in the breast tumour microenvironment, may contribute to cancer progression through interaction with tumour cells. Nonetheless, little is known about the details o...

Subject

Metastasis

Cancer research

Integrin

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