circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.

X, Zhang; Y, Xu; Z, Qian; W, Zheng; Q, Wu; Y, Chen; G, Zhu; Y, Liu; Z, Bian; W, Xu; Y, Zhang; F, Sun; Q, Pan; J, Wang; L, Du; Y, Yu

doi:10.1038/s41419-018-1132-6

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circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.

Shared by NobleBlocks on Oct 25, 2018 • 12:00 AM UTC

Authors:

Zhang X

Xu Y

Qian Z

Abstract

Some types of circular RNA (circRNA) are aberrantly expressed in human diseases including hepatocellular carcinoma (HCC). However, its regulation mechanism and diagnostic roles are largely unknown. Here, we identified that circRNA_104075 (circ_104075) was highly expressed in HCC tissues, cell lines ...

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